- 专利标题: Methods for enhancing the efficacy of a tumor-directed immune response
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申请号: US15300614申请日: 2015-04-02
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公开(公告)号: US10478491B2公开(公告)日: 2019-11-19
- 发明人: Samir Khleif
- 申请人: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
- 申请人地址: US GA Augusta
- 专利权人: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
- 当前专利权人: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
- 当前专利权人地址: US GA Augusta
- 代理机构: McDonnell Boehnen Hulbert & Berghoff LLP
- 国际申请: PCT/US2015/024034 WO 20150402
- 国际公布: WO2015/153857 WO 20151008
- 主分类号: A61K39/39
- IPC分类号: A61K39/39 ; A61K39/395 ; A61K39/00 ; A61K9/00 ; C07K16/28
摘要:
As described below, the present invention features methods for enhancing the efficacy of a tumor antigen in inducing an anti-cancer immune response in a subject by administering an OX40 agonist and an Indoleamine 2,3-dioxygenase (IDO) inhibitor with the tumor antigen.
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