A method and system for determining remaining useful life of an in-use injector of a reciprocating engine is disclosed. The method includes determining nozzle wear relationship data for different duty cycles of the in-use injector, and using the nozzle wear relationship data together with operating parameters for the reciprocating engine, and emission relationship data to determine actual emission levels for the in-use injector based on the wear relationship data and the emission relationship data. The method and system further include determining remaining useful life of the in-use injector based on actual emission levels and the nozzle wear relationship data; and controlling an operation of the reciprocating engine based on the actual emission levels.