Systems and methods for implementing access control by systems-on-chip (SoCs). An example SoC may comprise: an access control unit comprising a secure memory for storing access control data, the access control unit to: receive a message comprising an access control data item; store the access control data item in the secure memory; perform at least one of: authenticating the message using a message digest function, or validating contents of the secure memory by comparing a stored reference value with a calculated value of a message digest function of the contents of the secure memory; and control, in view of the access control data item, access by an initiator device to a target device.