This disclosure describes, in part, context-driven device arbitration techniques to select a speech interface device from multiple speech interface devices to provide a response to a command included in a speech utterance of a user. In some examples, the context-driven arbitration techniques may include executing multiple pipeline instances to analyze audio signals and device metadata received from each of the multiple speech interface devices which detected the speech utterance. A remote speech processing service may execute the multiple pipeline instances and analyze the audio signals and/or metadata, at various stages of the pipeline instances, to determine which speech interface device is to respond to the speech utterance.