The present disclosure relates to a pre-5th-generation (5G) or 5G communication system to be provided for supporting higher data rates beyond 4th-generation (4G) communication system such as a long term evolution (LTE). A method for cancelling a self-interference (SI) signal in a communication system supporting a full-duplex scheme is provided. The method includes estimating an SI channel, performing a pre-filtering operation on a transmission signal based on the estimated SI channel, generating copied-SI signals based on the estimated SI channel, and cancelling an SI signal based on the copied-SI signals, wherein the pre-filtering operation includes an operation for decreasing a number of SI signals.