Methods and devices for configurable sequence usage for user equipment (UE) uplink reference signaling are provided. In one provided method, a transmission reception point (TRP) in a wireless communication network receives a first UL reference signal (RS) associated with a first UL RS sequence from a first UE and receives a second UL RS associated with a second UL RS sequence from a second UE, the first and second UL RS sequences being non-orthogonal. In another provided method, A UE determines an UL RS sequence based on a UL RS sequence root, the UL RS sequence root being a UE-specific root and being independent of a cell identifier of a cell serving the UE. The UE sends an UL RS associated with the UL RS sequence, the UL RS sequence being a Zadoff-Chu sequence.