发明授权
- 专利标题： Monocyclic β-lactam-siderophore conjugate, and preparation method and use thereof
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申请号： US16251486申请日： 2019-01-18
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公开(公告)号： US10501454B2公开(公告)日： 2019-12-10
- 发明人: Yushe Yang , Liang Tan , Qunhuan Kou
- 申请人： Yushe Yang , Liang Tan , Qunhuan Kou
- 申请人地址： CN Shanghai
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： CN Shanghai
- 代理机构： Reinhart Boerner Van Deuren P.C.
- 优先权： CN201610578272 20160721
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; A61P31/04
摘要：
The present disclosure relates to the field of pharmaceutical synthesis, and more particularly, relates to a monocyclic β-lactam-siderophore conjugate as well as a method for synthesizing same and its use in the treatment of bacterial infectious diseases. Provided are a monocyclic β-lactam-siderophore conjugate represented by formula (I) as described herein, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a method for synthesizing same, and a use thereof in treating bacterial infectious diseases.
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