Invention Grant
- Patent Title: Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same
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Application No.: US16014355Application Date: 2018-06-21
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Publication No.: US10508267B2Publication Date: 2019-12-17
- Inventor: Peter Kratzsch , Mara Boenitz-Dulat , Daniela Beck , Thomas Streidl , Stacy Hunt DuVall
- Applicant: Roche Diagnostics Operations, Inc. , Roche Diabetes Care, Inc.
- Applicant Address: US IN Indianapolis US IN Indianapolis
- Assignee: Roche Diagnostics Operations, Inc.,Roche Diabetes Care, Inc.
- Current Assignee: Roche Diagnostics Operations, Inc.,Roche Diabetes Care, Inc.
- Current Assignee Address: US IN Indianapolis US IN Indianapolis
- Agency: Dinsmore & Shohl LLP
- Priority: EP16165421 20160414
- Main IPC: C12N9/04
- IPC: C12N9/04 ; C12Q1/54 ; C12Q1/32
Abstract:
The present disclosure relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell having the mutant 3-HBDH or the nucleic acid, and/or a method of determining the amount or concentration of 3-hydroxybutyrate in a sample. Also disclosed is the use of the mutant 3-HBDH for determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
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