A system and method for protecting a universal serial bus device from being used in an attack during communication between a communication device and an accessory device is disclosed. A protection device inserted between them through a USB link performs steps of receiving a message from the accessory device, including fields of characteristics of the accessory device; generating a random identifier; sending it to the communication device that creates a registration rule based on the generated random identifier; modifying an intercepted response from the accessory device to a request from the communication device, the request being dedicated to get a value associated with a serial number of the accessory device, by including the generated random identifier; and sending the modified response to the communication device, the modified response triggering a query for registration of the accessory device by means of the modified response and the created registration rule.