- 专利标题： Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers
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申请号： US15034799申请日： 2014-11-06
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公开(公告)号： US10517822B2公开(公告)日： 2019-12-31
- 发明人: Wenbin Lin , Chunbai He , Demin Liu
- 申请人： The University of Chicago , The University of North Carolina at Chapel Hill
- 申请人地址： US IL Chicago US NC Chapel Hill
- 专利权人： The University of Chicago,The University of North Carolina at Chapel Hill
- 当前专利权人： The University of Chicago,The University of North Carolina at Chapel Hill
- 当前专利权人地址： US IL Chicago US NC Chapel Hill
- 代理机构： Jenkins, Wilson, Taylor & Hunt, P.A.
- 国际申请： PCT/US2014/064388 WO 20141106
- 国际公布： WO2015/069926 WO 20150514
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K31/663 ; A61K9/51 ; C12N15/11 ; A61K45/06 ; A61K31/664 ; A61K31/713 ; C12N15/113
摘要：
Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described.
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