Techniques are disclosed relating to relating to a public key infrastructure (PKI). In one embodiment, an integrated circuit is disclosed that includes at least one processor and a secure circuit isolated from access by the processor except through a mailbox mechanism. The secure circuit is configured to generate a key pair having a public key and a private key, and to issue, to a certificate authority (CA), a certificate signing request (CSR) for a certificate corresponding to the key pair. In some embodiments, the secure circuit may be configured to receive, via the mailbox mechanism, a first request from an application executing on the processor to issue a certificate to the application. The secure circuit may also be configured to perform, in response to a second request, a cryptographic operation using a public key circuit included in the secure circuit.