Invention Grant
- Patent Title: Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain
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Application No.: US15727402Application Date: 2017-10-06
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Publication No.: US10525083B2Publication Date: 2020-01-07
- Inventor: Barbara Brannetti , Jennifer Brogdon , Boris Engels , Brian Granda , Lu Huang , Ming Lei , Na Li , Jimin Zhang , Carla Guimaraes
- Applicant: Novartis AG , The Trustees of the University of Pennsylvania
- Applicant Address: CH Basel US PA Philadelphia
- Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee Address: CH Basel US PA Philadelphia
- Agency: Lando & Anastasi, LLP
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61P35/00 ; A61K38/17 ; C12N15/85 ; C07K16/28 ; A61K39/00
Abstract:
The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.
Public/Granted literature
- US20180125892A1 TREATMENT OF CANCER USING CHIMERIC ANTIGEN RECEPTORS Public/Granted day:2018-05-10
Information query
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