Certain aspects of present invention relate to an electronic cigarette having tamper-proof locking mechanisms. In certain embodiments, the electronic cigarette may include: an electronic cigarette body, a tamper-proof mouthpiece connector locking mechanism threadedly connected to electronic cigarette body, and a tamper-proof power connector locking mechanism threadedly connected to electronic cigarette body. When a user pushes tamper-proof mouthpiece connector locking mechanism towards electronic cigarette body, tamper-proof mouthpiece connector locking mechanism is locked such that the user is able to remove a mouthpiece connector from electronic cigarette body to refill e-liquid for the electronic cigarette. When user pushes tamper-proof power connector locking mechanism towards electronic cigarette body, tamper-proof power connector locking mechanism is locked such that user is able to remove a power connector from electronic cigarette body to replace a vaporizer, a heater for the vaporizer, and e-liquid storage medium of the electronic cigarette.