The present invention relates to comprehensive systems and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems and methods are provided for identifying and treating a target tissue region adjusting for ablation-related anatomical changes (e.g., tissue contraction).