A protective case, sized and shaped to encase a mobile device such as a smartphone or a tablet computer, includes a top section and a bottom section. The top section and bottom section are capable of being engaged to one another in a closed relationship, in which the mobile device may be hermetically sealed or isolated from the outside environment. The top section and bottom section may be readily engaged to or disengaged from one another. Embodiments of the protective case may include membrane that includes a first membrane portion and a second membrane portion, the membrane portions having different qualities.