Systems and methods for multi-factor authentication in virtual, augmented, and mixed reality (xR) applications are described. In some embodiments, an xR headset may include a processor and a memory coupled to the processor, the memory comprising program instructions stored thereon that, upon execution, cause the xR headset to: authenticate a user wearing the xR headset, and, in response to the authentication, log the user into an Information Handling System (IHS) distinct from the xR headset.