- 专利标题： Low concentration antibody formulations
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申请号： US14775900申请日： 2014-03-13
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公开(公告)号： US10537638B2公开(公告)日： 2020-01-21
- 发明人: George Crotts , Sorina Morar-Mitrica
- 申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
- 申请人地址： GB Brentford, Middlesex
- 专利权人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
- 当前专利权人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
- 当前专利权人地址： GB Brentford, Middlesex
- 代理商 Donald Huddler; Duke M. Fitch; Edward R. Gimmi
- 国际申请： PCT/IB2014/059757 WO 20140313
- 国际公布： WO2014/141152 WO 20140918
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; A61K47/18 ; A61K47/26 ; A61K9/00
摘要：
The present invention is directed formulations for low concentrations of therapeutic proteins and methods of making the same. In one aspect the present invention is directed to a formulation for a therapeutic protein comprising: a) the therapeutic protein; and b) a surfactant; wherein the molar ratio of surfactant to therapeutic protein is at least 100. In another aspect the present invention is directed to a formulation for a therapeutic protein comprising: a) the therapeutic protein; and b) an antioxidant, wherein the molar ratio of antioxidant to therapeutic protein is at least 750.
公开/授权文献
- US20160000916A1 LOW CONCENTRATION ANTIBODY FORMULATIONS 公开/授权日：2016-01-07