Methods, apparatus, systems, and articles of manufacture to enable status change detection in a low power mode of a microcontroller unit are disclosed herein. An example integrated circuit (IC) includes a controller to determine that the IC is to enter a low power mode. The example IC includes a universal serial bus (USB) physical layer integrated circuit including a transceiver and a detector circuit. The transceiver is disabled while in the low power mode. The detector circuit is enabled while in the low power mode. The detector circuit is to determine whether a pinout of a USB receptacle is shorted to ground. The example IC includes a power control module (PCM) to disable the controller when entering the low power mode. Upon receipt of an indication that the ID pinout of the USB receptacle is shorted to the ground, the PCM initiates a boot sequence.