Implementations generally relate to locking a camera onto a sub-region to capture images of the sub-region with a moving camera. In some implementations, a method includes determining a first region in a scene detected by a camera while the camera is in a first physical position. The method further includes receiving user input to target a sub-region within the first capture region of the scene and capturing the first image of the sub-region while the camera is in the first physical position. The first image is displayed in a fixed orientation on a preview portion of a display screen. The camera is moved to a second physical position and a second capture region of the scene is detected. The method further includes capturing a second image is of the sub-region and displaying it in the fixed orientation on the preview portion of the display screen. The second image is effective to inform a user of whether capture of the sub-region is altered by camera movement.