A pixel structure including a data transistor, a switching transistor, a driving transistor, a compensation transistor, an illumination transistor, an organic light-emitting diode (OLED) and a first capacitor is provided. The data transistor transmits a data signal to a node according to a scan signal. The switching transistor provides a first reference signal to the node according to a first illumination signal. The driving transistor includes a gate, a source receiving a first operation voltage and a drain. The compensation transistor is coupled between the gate and the drain and receives a control signal. The illumination transistor receives a second illumination signal and is coupled to the drain. The OLED includes an anode coupled to the illumination transistor and a cathode receiving a second operation voltage. The first capacitor is coupled between the node and the gate.