A vehicle-based remote control system and method are provided herein. A first in-vehicle device and a second in-vehicle device are provided. The second in-vehicle device includes a user-input mechanism having at least one actuatable member, and a controller programmed to respond to input from the user-input mechanism. Upon actuation of the at least one actuatable member, the controller prompts the first in-vehicle device to transmit a pre-recorded user voice command assigned to the at least one actuatable member. The pre-recorded user voice command is transmitted to a server. The server processes the pre-recorded user voice command and generates a command for executing an action specified by the pre-recorded user voice command. The command is executed by one or more smart devices located remotely from a vehicle.