- 专利标题： Humanized light chain mice
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申请号： US15585023申请日： 2017-05-02
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公开(公告)号： US10561124B2公开(公告)日： 2020-02-18
- 发明人: Lynn Macdonald , Cagan Gurer , Karolina A. Hosiawa , Sean Stevens , Andrew J. Murphy
- 申请人： Regeneron Pharmaceuticals, Inc.
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 代理机构： Choate, Hall & Stewart LLP
- 代理商 Brenda Herschbach Jarrell; Stephanie L. Schonewald
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C07K16/46 ; C12N9/64 ; C07K16/28
摘要：
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a mouse, wherein the non-human animals express a human immunoglobulin heavy chain variable domain and a cognate human immunoglobulin λ light chain variable domain.
公开/授权文献
- US20170332609A1 HUMANIZED LIGHT CHAIN MICE 公开/授权日：2017-11-23