In an example implementation, a system includes one or more memory devices configured to store computer readable instructions, and a treatment adjustment engine that includes one or more processing devices. The treatment adjustment engine is configured to obtain a first image of an eye of a subject, and a second image of the eye of the subject. The second image is captured in the presence of an electronic light source. The treatment adjustment engine is further configured to determine, based on the first and second images, one or more metrics representing shapes of the iris and pupil in the corresponding images, and determine, based on the one or more metrics, a pupillometry measure of the subject. The treatment adjustment engine is also configured to generate a signal for adjusting a cardiopulmonary therapy based on the determined pupillometry measure.