- 专利标题： Immunoconjugates with an intracellularly-cleavable linkage
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申请号： US15612672申请日： 2017-06-02
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公开(公告)号： US10561738B2公开(公告)日： 2020-02-18
- 发明人: Serengulam V. Govindan , Sung-Ju Moon , David M. Goldenberg
- 申请人： Immunomedics, Inc.
- 申请人地址： US NJ Morris Plains
- 专利权人： Immunomedics, Inc.
- 当前专利权人： Immunomedics, Inc.
- 当前专利权人地址： US NJ Morris Plains
- 代理商 Richard A. Nakashima
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07K16/10 ; C07K16/28 ; C07K16/30 ; C07D491/22 ; A61K31/4745 ; C07K16/18 ; A61K45/06 ; A61N5/10 ; A61K39/00
摘要：
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
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