- 专利标题: Bridged piperidine derivatives
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申请号: US16004145申请日: 2018-06-08
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公开(公告)号: US10562903B2公开(公告)日: 2020-02-18
- 发明人: Bjoern Bartels , Hasane Ratni , Karlheinz Baumann , Guido Galley , Georg Jaeschke , Roland Jakob-Roetne , Anja Limberg , Werner Neidhart , Rosa Maria Rodriguez-Sarmiento
- 申请人: Hoffmann-La Roche Inc.
- 申请人地址: US NJ Little Falls
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Little Falls
- 代理机构: Genentech, Inc.
- 代理商 Richard G. A. Bone
- 优先权: EP15199260 20151210
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D471/04 ; A61P25/28
摘要:
The present invention relates to a compound of formula wherein HetAr is a five or six membered hetaryl group, containing one, two or three heteroatoms, selected from N, O or S; R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, halogen, or lower alkoxy; R2 is lower alkyl substituted by halogen, —CH2—C3-6-cycloalkyl, substituted by one or two substituents, selected from lower alkyl substituted by halogen or halogen, or is lower alkenyl substituted by halogen; R3 is hydrogen, lower alkyl substituted by halogen, lower alkyl, halogen, C3-6-cycloalkyl or lower alkyl substituted by hydroxy; n is 1 or 2; for n=2, R1 can be independent to each other; Y is CH or N; or to a pharmaceutically active acid addition salt thereof, to a racemic mixture or its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
公开/授权文献
- US20190010156A1 BRIDGED PIPERIDINE DERIVATIVES 公开/授权日:2019-01-10
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