Invention Grant
- Patent Title: Method for producing injectable formulations of blood-derived protein materials, and materials obtained using said method
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Application No.: US14110594Application Date: 2011-04-08
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Publication No.: US10562958B2Publication Date: 2020-02-18
- Inventor: Álvaro Segura Ruiz , Mariángela Vargas Arroyo , Guillermo León Montero , Mauren Villalta Arrieta , María Herrera Vega , Yamileth Angulo Ugalde
- Applicant: Álvaro Segura Ruiz , Mariángela Vargas Arroyo , Guillermo León Montero , Mauren Villalta Arrieta , María Herrera Vega , Yamileth Angulo Ugalde
- Applicant Address: CR San Jose
- Assignee: UNIVERSIDAD DE COSTA RICA
- Current Assignee: UNIVERSIDAD DE COSTA RICA
- Current Assignee Address: CR San Jose
- Agency: Lucas & Mercanti, LLP
- International Application: PCT/CR2011/000001 WO 20110408
- International Announcement: WO2012/136172 WO 20121011
- Main IPC: C07K14/765
- IPC: C07K14/765 ; C07K16/06 ; C07K16/18 ; C07K1/16 ; C07K1/36 ; C07K1/34 ; A61L2/00
Abstract:
A method for producing injectable pharmaceutical formulations of blood-derived protein materials includes the steps of fractioning the source material in a polymer/salt aqueous two-phase system in the presence of phenol, purifying the top phase of the system by means of precipitation with caprylic acid and purifying the bottom phase by means of thermocoagulation, increasing the purity of the materials in both phases through chromatography, removing viral particles by means of the nanofiltration of both preparations, and formulating, stabilizing, and packaging the resulting materials.
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