Provided are an apparatus and method for detecting an anomaly in a plant pipe using multiple meta-learning. When a multi-sensor data stream about a plant pipe is received, each of a plurality of meta-learning modules for processing different packet section ranges, extracts one or more preset types of features from sensor data of packet section ranges set according to trend from an arbitrary reception time point, generates 2D image features of the features according to multi-sensor-specific times, generates 3D volume features by accumulating the 2D image features in a depth direction according to multiple sensors, and learns the 3D volume features in parallel through multi-sensor-specific learning modules. Results of the learning of the meta-learning modules are aggregated, and it is determined whether there is an anomaly in a plant pipe according to a learning result selected based on an optimal combination of multiple features, multiple sensors, and multiple packet sections.