Embodiments of the present disclosure relate to systems and methods for controlling power generation plant operations via a human-machine interface. In one embodiment, a method can provide: receiving a user selection of a power generation plant component in a first navigation menu of a human-machine interface (HMI); based at least in part on the user selection, generating a second navigation menu of the HMI; receiving a subsequent user selection of a subcomponent in the second navigation menu of the HMI, wherein the subcomponent is associated with the power generation plant component; generating a control region for the HMI, the control region operable to manipulate the subcomponent; receiving a user input for the control region; and based at least in part on the user input, facilitating manipulation of one or more operations of the subcomponent.