An example of a system may include a lead including a distal electrode portion. The distal electrode portion may be configured to at least partially encircle a sympathetic chain in a lumbar region or thoracic region. The distal electrode portion may include at least one electrode oriented toward the sympathetic chain when the distal electrode portion at least partially encircles the sympathetic chain. The distal portion may include at least one anchoring site configured for use to mechanically secure the distal electrode portion to tissue proximate to the sympathetic chain. The lead may have a strain relief proximate to the distal electrode portion.