Systems, methods, and software described herein provide accelerated input and output of data in a work process. In one example, a method of operating a support process within a computing system for providing accelerated input and output for a work process includes monitoring for a file mapping attempt initiated by the work process. The method further includes, in response to the file mapping attempt, identifying a first region in memory already allocated to a cache service, and associating the first region in memory with the work process.