Invention Grant
- Patent Title: Methods and compositions for inhibiting the interaction of menin with MLL proteins
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Application No.: US15578837Application Date: 2016-06-03
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Publication No.: US10588907B2Publication Date: 2020-03-17
- Inventor: Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jonathan Pollock , Liansheng Li , Tao Wu , Jun Feng , Pingda Ren , Yi Liu
- Applicant: KURA ONCOLOGY, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US CA San Diego US MI Ann Arbor
- Assignee: KURA ONCOLOGY, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: KURA ONCOLOGY, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US CA San Diego US MI Ann Arbor
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2016/035869 WO 20160603
- International Announcement: WO2016/197027 WO 20161208
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D401/14 ; A61K31/519 ; A61P35/02 ; A61P3/10 ; A61K31/5377 ; A61K31/541
Abstract:
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.
Public/Granted literature
- US20180243303A1 METHODS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF MENIN WITH MLL PROTEINS Public/Granted day:2018-08-30
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