A wheel shape follow-up burr brushing device can brush burrs from a front, a back cavity and a spoke root groove of the wheel. The heights of brushes are adjusted, so that the brushes follow up the shape of the front, the back cavity and the spoke root groove of the wheel. The wheel is put onto a positioning roller bed by a manipulator, a positioning clamping cylinder drives four clamping wheels to clamp the wheel, four clamping wheel drive motors drive the wheel to be in a low-speed rotating state; two second cylinders drive a second rotating table to be fed downwards, two first cylinders drive a first rotating table to be fed upwards, and the rotating wheel is matched with the rotating brushes to brush burrs from the front, the back cavity and the spoke root groove of the wheel.