- 专利标题： Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
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申请号： US16574500申请日： 2019-09-18
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公开(公告)号： US10604547B2公开(公告)日： 2020-03-31
- 发明人: Matthew T. Burger , Yunho Jin , Tetsuo Uno
- 申请人： NOVARTIS AG
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理机构： Genomics Institute of the Novartis Research Foundation
- 代理商 Daniel E. Raymond
- 主分类号： C07K7/64
- IPC分类号： C07K7/64 ; A61P35/00 ; A61K47/68
摘要：
The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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