Invention Grant
- Patent Title: Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
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Application No.: US16574500Application Date: 2019-09-18
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Publication No.: US10604547B2Publication Date: 2020-03-31
- Inventor: Matthew T. Burger , Yunho Jin , Tetsuo Uno
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Daniel E. Raymond
- Main IPC: C07K7/64
- IPC: C07K7/64 ; A61P35/00 ; A61K47/68
Abstract:
The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
Public/Granted literature
- US20200024311A1 AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE Public/Granted day:2020-01-23
Information query
