- 专利标题： Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia and cancer
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申请号： US15912358申请日： 2018-03-05
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公开(公告)号： US10604565B2公开(公告)日： 2020-03-31
- 发明人: Jörg Wischhusen , Markus Junker , Tina Schäfer , Dirk Pühringer
- 申请人： JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG
- 申请人地址： DE Würzburg
- 专利权人： JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG
- 当前专利权人： JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG
- 当前专利权人地址： DE Würzburg
- 代理机构： Lathrop GPM LLP
- 代理商 Andrew T. Wilkins; Rebecca Wright
- 优先权： GB1405475.3 20140326; GB1405477.9 20140326
- 主分类号： C07K16/22
- IPC分类号： C07K16/22 ; A61K39/00 ; A61K39/395 ; C07K16/00 ; C07K16/18 ; C12N5/10 ; C12N15/12 ; C12N15/13 ; C12N15/63
摘要：
The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric antibodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine antibodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.
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