Invention Grant
- Patent Title: Diagnosis and therapy of cancer involving cancer stem cells
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Application No.: US14904011Application Date: 2014-07-30
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Publication No.: US10604568B2Publication Date: 2020-03-31
- Inventor: Ugur Sahin , Ozlem Tureci , Korden Walter , Meike Wagner , Maria Kreuzberg , Sabine Hacker , Stefan Jacobs
- Applicant: BioNTech AG , Astellas Pharma Inc. , TRON-TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH
- Applicant Address: DE Mainz DE Mainz JP Tokyo
- Assignee: BioN Tech AG,TRON-TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH,Astellas Pharma Inc.
- Current Assignee: BioN Tech AG,TRON-TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH,Astellas Pharma Inc.
- Current Assignee Address: DE Mainz DE Mainz JP Tokyo
- Agency: McAndrews, Held & Malloy, Ltd.
- Priority: WOPCT/EP2013/002272 20130731
- International Application: PCT/EP2014/066330 WO 20140730
- International Announcement: WO2015/014870 WO 20150205
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K47/68 ; A61K31/337 ; A61K31/5365 ; A61K31/7048 ; A61K31/7064 ; C07K16/28 ; G01N33/574 ; A61K33/24 ; A61N5/10 ; C07K16/30 ; A61K39/00
Abstract:
The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
Public/Granted literature
- US20160159901A1 DIAGNOSIS AND THERAPY OF CANCER INVOLVING CANCER STEM CELLS Public/Granted day:2016-06-09
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