The present disclosure is directed to an integrated combustor nozzle for a segmented annular combustion system. The integrated combustor nozzle includes an outer liner segment, an inner liner segment, and a fuel injection panel extending radially between the outer liner segment and the inner liner segment. The fuel injection panel includes a first side wall, a second side wall, and a plurality of premixing channels between the first and second side walls, each of the premixing channels having an outlet on one of the first and second side walls. The aft end of the fuel injection panel defines a turbine nozzle.