A touch panel driving apparatus generates a differential signal corresponding to a detection result of a touch panel. The touch panel driving apparatus includes a driving circuit, a first integrating sampling circuit, and a second integrating sampling circuit. The first integrating sampling circuit generates a first end signal of the differential signal. The second integrating sampling circuit generates a second end signal of the differential signal. When a touch event does not occur, a level of the first end signal and a level of the second end signal are in a common mode signal range of the differential signal. When the touch event occurs, the first integrating sampling circuit pulls up the level of the first end signal out of the common mode signal range, and the second integrating sampling circuit pulls down the level of the second end signal out of the common mode signal range.