A tree-dimensional (3D) touch panel and a manufacturing method thereof, a touch drive device and method, and a display device are provided. The 3D touch panel includes a display backplate and a cover plate opposite to each other. The display backplate includes a display substrate, a plurality of first touch electrodes, first wirings, and a plurality of spacers. The cover plate includes a cover plate substrate, a plurality of second touch electrodes and second wirings formed on a surface of the cover plate substrate facing the display backplate, and a position touch layer formed on a surface of the cover plate substrate away from the display backplate. The position touch layer is configured to detect a touch position; and the first touch electrodes and the second touch electrodes correspond to each other in position and are both disposed at the spacers.