Responsive grid layouts for graphic design are described. In one example, a system of a digital medium environment is configured to generate responsive grid layouts for graphic design. The system includes a layout module implemented at least partially in hardware of the computing device to generate a plurality of grid layouts each having at least one cell configured to be mapped to at least one design element of digital content. The system also includes a scoring module implemented at least partially in hardware of a computing device to assign scores to the plurality of grid layouts based on aesthetic criteria and an output module implemented at least partially in hardware of a computing device to output at least one grid layout of the plurality of grid layouts for recommendation to a user based on the scores.