![N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use](/docs/US/2020-05-12/US10647717B2/abs.jpg.600x600.jpg)
- 专利标题： N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use
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申请号： US16444495申请日： 2019-06-18
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公开(公告)号： US10647717B2公开(公告)日： 2020-05-12
- 发明人: Rhalid Akkari , Luke Jonathan Alvey , Xavier Marie Bock , Brian S. Brown , Pieter Isabelle Roger Claes , Marlon D. Cowart , Elsa De Lemos , Nicolas Desroy , Béranger Duthion , Gregory A. Gfesser , Romain Luc Marie Gosmini , Christopher Gaëtan Housseman , Koen Karel Jansen , Jianguo Ji , Philip R. Kym , Jean-Michel Lefrancois , Oscar Mammoliti , Christel Jeanne Marie Menet , Nuria Merayo Merayo , Gregory John Robert Newsome , Adeline Marie Elise Palisse , Sachin V. Patel , Matthieu Rafaël Pizzonero , Anurupa Shrestha , Elizabeth C. Swift , Steven Emiel Van der Plas , Xueqing Wang , Ann de Blieck
- 申请人： AbbVie S.à.r.l. , Galapagos NV
- 申请人地址： LU Luxembourg BE Mechelen
- 专利权人： AbbVie S.á.r.l.,Galapagos NV
- 当前专利权人： AbbVie S.á.r.l.,Galapagos NV
- 当前专利权人地址： LU Luxembourg BE Mechelen
- 代理机构： Quarles & Brady LLP
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; C07D519/00 ; A61K31/4545 ; A61K31/506 ; A61K31/5377 ; A61K45/06
![N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use](/abs-image/US/2020/05/12/US10647717B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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