- 专利标题： Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
-
申请号： US15579115申请日： 2016-06-20
-
公开(公告)号： US10647727B2公开(公告)日： 2020-05-12
- 发明人: Gregori J. Morriello , Lehua Chang , Ashley Forster , Richard Berger , Kausik K. Nanda , William D. Shipe
- 申请人： Merck Sharp & Dohme Corp. , Gregori J. Morriello , Michael P. Dwyer , Lehua Chang , Yili Chen , Ming Wang , Ashley Forster , Richard Berger , Kausik K. Nanda , Jamie L. Bunda , William D. Shipe
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Dianne Pecoraro; John C. Todaro
- 国际申请： PCT/US2016/038292 WO 20160620
- 国际公布： WO2016/209749 WO 20161229
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D498/04 ; C07D473/34 ; A61P25/06 ; A61P25/28 ; A61P25/18 ; A61P25/16
摘要：
The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.