A control method of an internal combustion engine and an internal combustion engine applying the same. Each cylinder is provided with a throttle valve, or a plurality of paralleled throttle valves are employed to supply air for different cylinders or cylinder groups, so that different cylinders are provided with different inlet pressure and inlet airflow, different spark ignition timing (phase angle), different injection timing (phase angle), and different injection quantity, and in a complete work cycle, some cylinders of the engine operate under a compression ignition combustion mode, and some cylinders of the engine operate under a spark ignition combustion mode. When the conditions for compression ignition combustion mode are satisfied, the cylinders adopt the compression ignition combustion mode as much as possible, so as to improve the thermal power efficiency of the engine. The internal combustion engine or vehicle installed with the control method has wide adaptability to different fuel with different ignition points, can detect the octane number of gasoline, and consume various octane number gasoline.