Systems and methods for a volumetric multi-selection interface for selecting multiple entities in three-dimensional (3D) space are provided. An example method includes generating a selection region within a three-dimensional space and receiving a selection path user input to define a selection path. The method also includes defining a selection volume based on the selection region and the selection path and selecting entities within the 3D space based on the selection volume. In some implementations, an alter selection region user input is received while the selection path is being defined. The size or shape of the selection region may be altered in response thereto.