Securing an endpoint against malicious activity includes encrypting a plurality of files on an endpoint to prevent unauthorized access to the plurality of files, receiving a request to access a file from a process executing on the endpoint, decrypting the file for the process, and monitoring a security state of the process. If the security state becomes a compromised state, a technique involves maintaining access to any open files (including the file decrypted for the process), prohibiting access to other files, and initiating a remediation of the process by facilitating a restart of the process. If the remediation is successful, access by the process to the plurality of files may be restored.