A surgical instrument system comprising an end effector, a shaft, a closure drive, a closure member, and a motor-powered firing drive is disclosed. The end effector comprises an elongate channel, a staple cartridge, a clamping member, and a firing member. The staple cartridge comprises a plurality of staples and a plurality of staple drivers. The clamping member is pivotably connected to the elongate channel and movable between an open position and a clamped position during a clamping motion. The firing member is movable within the elongate channel to engage the staple drivers and deploy the staples from the staple cartridge. The closure member is operably connected to the closure drive and is configured to translate in a proximal direction to pivot the clamping member to the clamped position. The motor-powered firing drive is operably connected to the firing member. The closure drive and the firing drive are independently actuatable.