A machine implemented method for prioritizing system interrupts in a processing system is provided. The method comprising: determining, at a supervisor module, for each interrupt, a relative interrupt priority in accordance with at least one interrupt parameter for said interrupt; prioritising, at said supervisor module, each said interrupt with respect to other interrupts of said system in compliance with said determined relative interrupt priority; and in response to a change to said at least one interrupt parameter during operation of said system, adjusting said determined relative interrupt priority, and re-prioritising each said interrupt with respect to said other interrupts of said system in compliance with said adjusted relative interrupt priority.