Described herein are systems, methods, and software to enhance virtualization connection management for virtual remote direct memory access (RDMA) devices. In one implementation, virtual machines may register with a hypervisor for the virtual machines, wherein the registration for each virtual machine includes at least one address for the virtual machine. Once registered, the hypervisor may identify a packet placed in a queue pair from a physical RDMA interface and determine whether a destination address in the packet corresponds to a virtual machine. If the destination address corresponds to a virtual machine, then the hypervisor may provide a callback to the virtual machine, wherein the callback provides access to the packet in the virtual machine as if the packet received at a virtual RDMA interface of the virtual machine.