A method includes manipulating segmented structure of interest, which is segmented from first reconstructed image data at a reference motion phase of interest, that is registered to second reconstructed image data at one or more other motion phases. The method further includes updating initial motion vector fields corresponding to the registration of the segmented structure of interest to the second reconstructed image data based on the manipulation. The method further includes reconstructing the projection data with a motion compensated reconstruction algorithm employing the updated motion vector fields.