A whole-process simulation experiment system has: a visualized model system with test samples and serving as a bearing device for the simulation of whole-process seepage of filling-type karst; a controllable support system supporting a visualized model box and controlling fluid seepage direction in the box by changing its inclination angle; a servo loading system controlling water pressure in the test process and providing four different loading modes for the box; a high-speed camera system recording water flow and particle motion in a transparent seepage model box in the seepage failure process; a comprehensive data measuring system monitoring and recording the change rules of factors including but not limited to seepage pressure, seepage amount and sand gushing amount in the seepage failure process; and an information analysis and feedback system recording and analyzing the seepage process and the whole seepage failure process in real time to achieve data processing and feedback.